Journal article
Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies
HB Nichols, MJ Schoemaker, J Cai, J Xu, LB Wright, MN Brook, ME Jones, HO Adami, L Baglietto, KA Bertrand, WJ Blot, MC Boutron-Ruault, M Dorronsoro, L Dossus, AH Eliassen, GG Giles, IT Gram, SE Hankinson, J Hoffman-Bolton, R Kaaks Show all
Annals of Internal Medicine | Published : 2019
DOI: 10.7326/M18-1323
Abstract
Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated. Objective: To characterize breast cancer risk in relation to recent childbirth. Design: Pooled analysis of individual-level data from 15 prospective cohort studies. Setting: The international Premenopausal Breast Cancer Collaborative Group. Participants: Women younger than 55 years. Measurements: During 9.6 million person-years of follow-up, 18 826 incident cases of breast cancer were diagnosed. Hazard ratios (HRs) and 95% CIs..
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Grants
Awarded by Ligue Contre le Cancer
Funding Acknowledgements
In part by the Avon Foundation (02-2014-080); funding from Breast Cancer Now and the U.K. National Health Service to the Royal Marsden-Institute of Cancer Research National Institute for Health Research Biomedical Research Centre; the Institute of Cancer Research, London; the National Institute of Environmental Health Sciences (Z01 ES044005) and National Cancer Institute (UM1 CA176726, UM1 CA186107, UM1 CA164974, R01 CA058420, R01 CA092447, and P50 CA168504) of the National Institutes of Health; the National Center for Advancing Translational Sciences (KL2-TR001109); the National Program of Cancer Registries of the Centers for Disease Control and Prevention and the Department of Energy; the Swedish Research Council and Swedish Cancer Society; the Japanese Ministry of Health, Labour and Welfare; the Hellenic Health Foundation; a Karolinska Institutet Distinguished Professor Award (2368/10-221); Cancer Council Victoria and the Australia National Health and Medical Research Council (209057, 396414, and 504711); the state of Maryland; and the Maryland Cigarette Restitution Fund. The coordination of EPIC (the European Prospective Investigation into Cancer and Nutrition) is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de 'Education Nationale, and Institut National de la Sante et de la Recherche Medicale (France); German Cancer Aid, German Cancer Research Center, and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sport, Netherlands Cancer Registry, LK Research Funds, Dutch Prevention Funds, Zorg Onderzoek Nederland, World Cancer Research Fund, and Statistics Netherlands (the Netherlands); ERC-2009-AdG 232997, Health Research Fund (FIS), PI13/00061 to Granada, PI13/01162 to EPIC Murcia, regional governments of Andalucia, Asturias, Basque Country, Murcia, and Navarra, and ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Research Council, and county councils of Skane and Vasterbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk and C570/A16491 and C8221/A19170 to EPIC-Oxford) and the Medical Research Council (1000143 to EPIC-Norfolk and MR/M012190/1 to EPIC-Oxford) (United Kingdom).